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Useful indicators can mirror the occurrence, development, and prognosis of diseases during normal biological processes, pathogenic processes, or pharmacological responses to therapeutic interventions ( 2 Blood biomarkers 2.1 Lewy body-related biomarkers 2.1.1 -Synuclein (-Syn) Eosinophilic inclusion bodies, or Lewy bodies, form in the cytoplasm of dopaminergic neurons remaining in the SN in patients with primary PD

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Funding This study was funded by the Fundao Grupo O Boticrio and RAN/ICMBio, the National Council for Scientific and Technological Development (CNPq) (case number 307071/2015-4), and the Higher Education Personnel Improvement CoordinationBrazil (CAPES) (Financial Code 001)