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The HLA-Cw6 is one of this regions most strongly associated alleles affecting disease onset, course, severity, comorbidities, and treatment outcomes ( While genetic factors are well documented in psoriasis, several environmental triggers, such as mechanical skin trauma and inflammation, infections, drugs, smoking, excessive alcohol intake, mental stress and microbiota/diet, and epigenetic modifications, may induce, trigger or exacerbate the disease

While palliative care facilities are better in hospital settings, community-based support systems have to be developed to provide help for a larger number of patients who do not have access to advanced medical care

J Pain Symptom Manage 42:788804 Kroly N, Mihly A, Dob E (2011) Comparative immunohistochemistry of synaptic markers in the rodent hippocampus in pilocarpine epilepsy

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