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E2 enhances epithelial tight junction integrity via estrogen receptor-mediated mechanisms, promoting selective nutrient absorption and limiting endotoxin translocation [72,73], whereas P4-dominant states may be associated with transient increases in permeability according to some studies [74]

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Semaglutide: the oral comparison point Semaglutide is the only GLP-1 receptor agonist with an FDA-approved oral formulation (Rybelsus)

The proposed bioactive compounds were ranked in ascending order based on their Area (%) values