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Melatonin: Pharmacology, Functions, and Therapeutic Benefits

The combination treatment alleviates the tumor immunosuppressive phenotype One of the challenges in cancer treatment is the immune suppression mediated by the tumor and its surrounding microenvironment, leading to poor therapeutic responsiveness

When unregulated, that signal can feed tumor formation or interfere with cellular apoptosis (natural cell death)

10.1007/s11064-008-9782-x
