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In a 12-week experimental study, rats fed with adenine developed hypertension and kidney dysfunction, conditions that were alleviated by supplementation with resveratrol butyrate monoester

conducted a study to elucidate the mechanism of ciprofloxacin nephrotoxicity and its attenuation by melatonin co-administration.121 They found that ciprofloxacin 100mg/kg/day, for 8 days, significantly increase the serum creatinine and BUN levels which were effectively restored with melatonin 10mg/kg co-administration

Additionally, menaquinone can induce both apoptotic and non-apoptotic cell death in cancer cells in solid tumors (104106)