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Z., Chachra, S

From the standpoint of therapeutic strategy, neuromodulation therapies, including noninvasive cerebellar stimulation and possibly transplantation in the near future, are recommended during the early stage when cerebellar reserve is preserved [105, 106]

Resveratrol modulates NF-B/JNK/MAPK signaling, SIRT1 activation, and microglial cytokine release, offering neuroinflammatory and anti-amyloid benefitsthough clinical outcomes remain mixed and oral bioavailability low (~0.5%), prompting exploration of improved formulations (48)

The exercise protocol involved 5 weekly sessions of treadmill running at an intensity of 6070% of maximum speed (23 m/min), including 2-min rest intervals, for a total duration of 8 weeks