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The hypoxic tumor microenvironment is considered one of the biggest obstacles for the development of anticancer drugs

B., et al., Preclinical Quality, Safety, and Efficacy of a human Embryonic Stem Cellderived Product for the Treatment of Parkinson's Disease, STEMPD, Cell Stem Cell 30, no

This differentiation plasticity can be attributed to the embryonic history of melanocytes, which are derived from the neural crest, a transient, migratory, and multi-potent population of cells that can differentiate into diverse cell types (Sauka-Spengler and Bronner-Fraser, 2008)

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