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A commercially available assay, Decision Dx-UM (Castle Biosciences), classifies the UM into two metastatic risk classes: At eight years, the survival rate for class 1 is 95%, whereas it is only 31% for class 2

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A variant in this gene in oculocutaneous albinism type 1 produces proteins with minimal to no activity, corresponding to the OCA1B and OCA1A phenotypes, respectively
