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GLP-1 receptor agonists work through an entirely different mechanism involving gut hormone signaling

As a thrombopoietin receptor agonist, Romiplostim activates cellular transcription pathways through the c-Mpl receptor (thrombopoietin receptor) to increase platelet production

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To adjust the impact of baseline HbA1c concentration on decreased blood glucose concentrations, GLP-1 RA responders were defined as an HbA1c reduction ratio [(HbA1c level at week 12) (HbA1c level at baseline)/(HbA1c level at baseline)] 0.12, whereas GLP-1 RA non-responders were defined as an HbA1c reduction ratio 99% and E value = 0 (access date: Jan 23, 2021) ( igraph and SpiecEasi were used for construction of the co-occurrence network with SparCC correlation coefficients (3739)