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Initial weeks (0-4 weeks): During treatment initiation, many patients experience decreased energy due to side effects

Doses start at 0.25 mg weekly, increasing every 4 weeks until reaching a maintenance dose of 2.4 mg weekly, if tolerated

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Lethargy was reported in 1% to less than 5% of patients receiving coated extended-release tablets, though not among those receiving the immediate-release product, dual-matrix extended-release tablets, or extended-release capsules