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Contraindications to Pepto-Bismol that Wegovy users should be aware of include: Salicylate hypersensitivity (including aspirin allergy) Under 16 years of age (risk of Reye's syndrome) Bleeding disorders Severe renal impairment Pregnancy and breastfeeding Important interactions include: Anticoagulants (especially warfarin) Other salicylates and NSAIDs Methotrexate Some antibiotics (tetracyclines, quinolones) reduced absorption Recommended approach : Use Pepto-Bismol only for mild, self-limiting symptoms during the initial adjustment period

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