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Semaglutide Nausea or vomiting Diarrhea or constipation Headache or dizziness Fatigue Injection site reactions Rare: pancreatitis or gallbladder issues Mounjaro Nausea or reduced appetite Diarrhea or constipation Stomach pain or indigestion Injection site reactions Headache or dizziness Rare: risk of thyroid tumors (in animal studies) Other potential tirzepatide side effects may include increased heart rate or allergic reactions in rare cases For a deeper breakdown of each symptom and tips on how to manage them, see our full guide on mounjaro side effects