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In phase 3 trials, maximal dose retatrutide demonstrated 29% placebo-adjusted weight loss at 68 weeks (albeit with higher discontinuation rates than semaglutide and tirzepatide)

Diabetes Coverage: Some insurance plans may cover GLP-1 medications for the treatment of type 2 diabetes, but coverage can vary widely

Microbial regulation of GLP-1 and L-cell biology

The patient information documents complement the recommendations in the guidance document.