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Tirzepatide, a dual GLP-1/GIP (glucose-dependent insulinotropic polypeptide) receptor agonist, has superior metabolic effects compared to GLP-1 RAs (glucagon-like peptide-1 receptor agonist) alone

doi: 10.1016/j.diabet.2018.12.001 [DOI] [PubMed] [Google Scholar] 35.Trujillo J

WEIGHTWATCHERS' STOCK SOARS AFTER SEQUENCE DEAL CLOSES These drugs aren't cosmetic treatments or quick fixes but rather "powerful, long-term injectable therapies designed to address the chronic disease of obesity," according to McGowan, and "demand close monitoring, robust nutritional support and expert medical supervision." "I frequently encountered patients requesting that weight loss shot without a comprehensive understanding of its implications," he continued

Earlier GLP-1R agonists could cross into the brain and do have effects on the mouse model of Alzheimers disease, but the newer drugs have been designed to stay in the blood for a very long time and do not really cross into the brain, said Hlscher