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High leptin levels have been tied to high blood pressure, obesity, heart disease, and stroke, as well as blood sugar-related problems

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Additional insights from the reports include: The most common eligibility requirements used to approve GLP-1 coverage are minimum body mass index (BMI) (90% corporate and 86% multiemployer and public employer), obesity with one other chronic disease (54% and 51%), and participating in a lifestyle modification program (29% and 34%)

NICE NG28 advises considering a GLP-1 receptor agonist in preference to a sulphonylurea when weight loss or avoidance of hypoglycaemia is a priority, though sulphonylureas remain appropriate options in selected patients
