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Infection points of the obesity indication were the FDA approval of high-dose semaglutide (Wegovy) in June 2021 and tirzepatide (Zepbound) in November 2023 specifically as chronic weight management drugs, where both drugs showed unprecedented efficacy in weight reduction, averaging 15-22% of baseline body weight in clinical trials

Participants in one study expressing dissatisfaction with their weight demonstrated self-consciousness and a negative body image, adversely affecting sexual satisfaction [47]

Three hours after LPS injection, there was an observed increase in GLP-1 levels that was not seen after saline injection

Higher body weight may affect the volume of distribution, though standard dosing protocols generally account for this variation