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As such, weight loss represents another important modality in OSA treatment, improving not only OSA symptoms and severity but also offering the potential to reduce cardiovascular risk, an effect not observed with PAP therapy [67]

Although our mouse studies suggest that tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the species difference in receptor pharmacology may limit extension of this interpretation to humans 25,26

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The result was a single peptide with subnanomolar, balanced activity at both incretin receptors and minimal activity at the glucagon receptor 40