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10.1016/j.molmet.2017.04.010 157
The receptor was pivotal to the ability to create long-lasting GLP-1 drugs for diabetes and obesity
The SURMOUNT-2 trial in adults with both obesity and type 2 diabetes saw a similar pattern, though weight loss was lower across the board (people with diabetes typically lose less weight on GLP-1 drugs)
GLP-1 from NTS is widely distributed to GLP-1 R in the hypothalamus and mesolimbic system that are involved in the perception of the reward value of the food and in the regulation of food intake [2]
