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Discovery of multi-receptor agonists for the GIPR and GLP-1R The multifactorial nature of physiological control of metabolism and body weight, coupled with the demonstration that gastric bypass procedures increase secretion of GLP-1 and several other gut-derived hormones, suggested that engineering medicines combining GLP-1R activity with other hormonal stimuli might offer superior clinical outcomes

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Rabizadeh S, Nakhjavani M, Esteghamati A (2019) Cardiovascular and renal benefits of SGLT2 inhibitors: a narrative review

And Clinical trials have been conducted to investigate the potential cognitive benefits of GLP-1R agonists in patients with AD