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These effects are likely primarily mediated through actions in various regions of the brain involved in the regulation of appetite and food intake [18], as supported by preclinical studies [1922], multiple human imaging studies [18], and the GLP-1R expression patterns in the human brain [9, 23]
It helps support appetite control
Sitagliptin/metformin also resulted in a greater reduction in fasting plasma glucose (FPG) levels when compared with placebo (31.1 mg/dL vs
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