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This is consistent with real-world situations where overweight and elderly patients often exhibit age-related physiological changes and increased susceptibility to AEs, indicating higher-risk subgroups requiring targeted monitoring
The PIONEER trial series, such as PIONEER 1 by Aroda VR et al
SGLT2-i reduces both systolic blood pressure (SBP) and diastolic blood pressure (DBP) across multiple trials and meta-analyses with reductions up to 8.6/4.3 mmHg, depending on the agent, dose and population studied
