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Sci Transl Med, 10(467):eaar7047
Evolution of DPP-4 independent GLP-1 degradation and decreased receptor activation may have evolved in response to GLP-1 in venom
Important safety considerations include a boxed warning for risk of thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and risks of pancreatitis, gallbladder disease, acute kidney injury with dehydration, and diabetic retinopathy complications with semaglutide
Some healthcare professionals may prescribe Ozempic off-label for weight loss because it may decrease body weight
