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Although to establish this completely would require more mechanistic evidence, a direct neurotoxic effect of cigarette smoking is compatible with reported associations in rodents between prenatal exposure to nicotine and reduced cingulate cortex volume, dopamine turnover, brain size, dendritic morphology and spine density

North Dakota law prohibits smoking, including the use of an e-cigarette, in all enclosed areas of public places and places of employment, as well as within 20 feet of entrances, exits, operable windows, air intakes, and ventilation systems of enclosed areas in which smoking is prohibited

As a result of this effort, the smoking ratio has been gradually decreasing