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These states have what economists consider a broad base

Nicotine and other toxic substances in tobacco interfere with oxygen delivery to nerve tissues, leading to chronic pain, weakness, and delayed recovery from neurological conditions

PMID 23334819
In 2019, teen smoking and vaping rates reached alarming highs, with over five million high school (27.5%) and middle school (10.5%) students reporting the regular use of tobacco products in the past 30 days
