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"EU Probes Cigarette Deal That May Have Aided Syria"

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Stage Two: Genetic Alterations Carcinogenic substances such as nitrosamines, polycyclic aromatic hydrocarbons (PAHs), and formaldehyde cause mutations in oncogenes and tumor suppressors (e.g., p53) present in the DNA of the mouth's lining

They found that the former enhanced the effects of the latter, as measured by activity levels, conditioned place preference, and various brain responses
