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However, this research has limitations: It used lower nicotine concentrations than many modern products The study was relatively small and focused on rectal tone specifically It didn't account for higher-strength products like 6mg ZYN pouches Higher-strength products like 6mg or 9mg ZYN pouches contain substantially more nicotine and may produce stronger digestive responses

Evidence from these findings demonstrates that the disruption of these processes leads to the lungs inability to maintain homeostasis and recover from injury, resulting in a reduction in mucociliary clearance

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