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Oxidative stress conditions lead to vascular endothelial dysfunction, expression of redox-sensitive genes, induction of inflammation, and development of atherosclerosis [69]

Michael Fiore of the Center for Tobacco Research and Intervention at the University of Wisconsin told INSIDER

The Impact of Nicotine on Oral Health Nicotine adversely affects oral health in several ways, including: Discoloration and Staining: Nicotine and tar in tobacco can cause significant staining of the teeth, leading to a yellowed or brown appearance
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