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Besides, nicotine mediates inflammation and fibrosis by TGF- production (by activation of STAT3) and upregulation of vimentin, -SMA, and fibronectin [296]
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Ce systme joue pourtant un rle dans la modulation de la douleur, ce qui explique pourquoi les personnes fumeuses douloureuses consomment souvent plus danalgsiques, dont les opiodes, pour obtenir un soulagement comparable
