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This reprogramming shifts it from a PANoptotic, lytic pro-inflammatory death lineage back towards a more controllable apoptotic and inflammatory resolution trajectory, thereby reducing acute exacerbations and structural progression while preserving the hosts anti-infection and immune surveillance capabilities as much as possible

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Tobacco executives say the fact that a patent has been filed doesn't mean the product is necessarily marketable or acceptable to consumers, but the sheer volume of patents shows that the industry has invested heavily in developing a safer cigarette even as its own executives were denying any link between smoking and disease