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Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-gamma/HIF-1alpha signaling and supports host defense

Selain itu terdapat faktor paparan sinar matahari, penggunaan bahan-bahan kimia pada kulit, hormon, dan kerusakan kulit yang juga bisa memicu produksi melanin

Specifically, our findings across both clinical cohorts and experimental models demonstrate that hepatic FPN downregulation in MASLD led to iron accumulation, which subsequently and profoundly altered hepatokine secretion profiles, particularly of fetuin-A and LECT2 via FoxO1 activation, ultimately promoting obesity, IR, and impaired thermogenesis

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