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Recent in vitro experiments have shown that tumor cells lacking TP53 produce a large amount of aspartic acid when cultured in vitro ( de novo synthesis of asparagine and supports tumor cell survival and proliferation in androgen-deprived or nutrient-limited environments

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Department of Genetics and Clinical Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland Abstract Reactive oxygen and nitrogen species can be generated endogenously (by mitochondria, peroxisomes, and phagocytic cells) and exogenously (by pollutions, UV exposure, xenobiotic compounds, and cigarette smoke)