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In addition, Anraku et al (59), using in vitro experiments, found that HNA1 affects the binding ability of Sites I and II [two specific drug binding sites, located in subdomains IIA and IIIA, respectively (69)], with a greater effect on Site II (23,59) (Fig
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Both functionally and morphologically, neurons look entirely different in various regions of the brain and under different disease states
Nonetheless, further studies are required to investigate the underlying molecular mechanisms to understand its therapeutic effects better
