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Preclinical FOXO4-DRI treatment reverses cognitive decline and neuropathology

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Cook N, 2023, 'A phase 1/2 study of dendrimer-enhanced (DEP) SN38 (SN38-SPL9111/DEP irinotecan) in patients with advanced solid tumours', MOLECULAR CANCER THERAPEUTICS , 22, Journal articles | 2023 O'day R

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doi:10.1016/j.soard.2013.04.017

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The published rodent literature has not reported overt toxicity at the studied amounts, but the available data are not equivalent to a regulated Phase 1/2 safety database

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