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[93] Because cancer cells utilize increased glycolysis, and because NAD enhances glycolysis, nicotinamide phosphoribosyltransferase (NAD salvage pathway) is often amplified in cancer cells

(ix) QU acts synergistically with CP via different mechanisms (interferes with topoisomerases I and II, interacts with estrogen receptor type II binding sites, and modulates various signaling pathways involved in cell proliferation, complementing CP effects on the formation of DNA adducts and ROS

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