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L.Schwegler-BerryD.PacurariM.et al
Cells were exposed to 0-, 50-, or 100-mM ethanol for 48 h, and the medium was changed every 24 h
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Mechanistically, the CD73/A2AR signaling cascade coordinates the de novo synthesis and consumption of GSH with GSSG accumulation and concomitant mitochondrial lipid peroxidation, which links potentially to PKA/E2F1dependent fine-tuning of the ratio of GSR to GPX4
