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The peptide also induces the expression of vascular endothelial growth factor (VEGF) and angiopoietin-1, promoting angiogenesis in injured tissues
doi: 10.1016/j.ygcen.2008.11.020 97 TriantaphyllopoulosKACartasDMiliouH

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Ibuprofen is insoluble in water, thus organic solvents such as ethanol, DMSO or dimethyl-formamide are needed for its pharmaceutic formulations that makes its safe applicability a challenge [70]
