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Like neutrophils, their capacity to phagocytose opsonized particles and to generate super-oxide anions plays a major role in eliciting tissue damage
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Importantly, this seems very much dependent upon the type of steroid in the formulation with studies in primates indicating that only estrogen could restore insulin sensitivity whereas medroxyprogesterone acetate (MPA) caused increased adiposity and reduced insulin sensitivity (Shadoan et al., 2003, 2007)
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