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On this basis, Rusciani and colleagues carried out a 3-year trial during which 81 patients with stage I and II melanoma and surgically removed lesions received low doses of recombinant interferon -2b (9 000 000 000 IU weekly) only, or a combination of interferon -2b (9 000 000 000 IU weekly) and CoQ 10 (400 mg/day)

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