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Consequently, we observed an important metabolic shift that reflects a reversion of cancer cells toward a more normal, differentiated phenotype with a reduction in the expression of Warburg genes and an upregulation of OXPHOS genes indicating a return to normal energy production through oxidative phosphorylation (Figure 2C)

To realize this expectation, researchers should not only rely on existing procedures for measuring skin permeation but also create a reliable method to selectively determine GHKCu in the presence of liposomes and the encapsulated complex

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