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The other twelve GST isozymes showed no mitigation effects on AFB 1 -induced toxicity, which might be due to the excessive GST activity depleting intracellular GSH so that its negative effects outweighed its weak detoxification ability [38]

Romero et al, 2017

Structurally similar to insulin, IGF-1 binds to specific receptors on cells, activating pathways that promote cell growth, protein synthesis, and repair

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