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Reproductive studies have been performed in rats and rabbits at doses up to 3.8 times the human dose on the basis of surface area and have revealed no evidence of impaired fertility or harm to the fetus due to levocarnitine

In addition, curcumin treatment attenuated the streptozotocin-induced oxidative stress by reducing the acetylcholinesterase activity and enhancing GCH content in hippocampus and cerebral cortex [299]

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However, the lack of efficacy in the active control group treated with rasagiline raises question on possible issues with study design and conduct (Hauser et al