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Appropriate dosage adjustments should be made for patients with impaired kidney function and duration of use should be as short as possible to minimize risks of undesired reactions [see Dosage and Administration (2.2)]

Sections (10 m) of SN and putamen from 12 subjects clinically diagnosed with PD and having marked pathological features including Lewy bodies and degeneration of dopaminergic terminals and cell bodies were examined

Reactivity and ionization of the active site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo