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DN exhibit clinical features generally not associated with CN (Fig

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3 Small molecules 3.1 Emerging therapeutics targeting Janus-activated kinase (JAK) signaling The Janus kinases family consists of JAK1, JAK2, JAK3, and TYK2, which is engaged in the important JAK/STAT pathway, exhibiting pleiotropic effects on transducing multiple extracellular signals involved in regulating proliferative signaling, differentiation, migration, and apoptotic properties (28)

Intraoral examination revealed asymptomatic, multiple, irregular, dark-brown-pigmented macules on the dorsal surface of the right tip of the tongue extending posteriorly, measuring 10.0 10.0mm in size (Fig.2A)