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425 Additionally, STUB1-mediated ubiquitination of IRE1 may be required for its phosphorylation and TRAF2 recruitment during ER stress 434 , while IRE1 sulfenylation appears necessary for TRAF2/ASK1/p38 activation (as well as being mutually exclusive with IRE1 phosphorylation and XBP1 splicing) under oxidative stress

Trends Mol Med 2024

Future research in this area holds significant potential to transform the landscape of autoimmune disease treatment

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