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Brensocatib, a serine protease inhibitor has shown promise in reducing inflammation and exacerbations in a phase 2 trial

These properties of microbial metabolites can directly affect sirtuin function, as sirtuins are involved in regulating oxidative stress and inflammation [136]

Cytosolic synthesis of GSH takes place in two ATP-dependent reactions catalyzed by glutamate-cysteine ligase (GCL) and glutathione synthase (GS)

Magnetic resonance imaging We sequentially conducted magnetic resonance imaging (MRI) of the brains of WT, GCLC-KO, PLX-administrated GCLC-KO, and GSDME-KO X GCLC-KO mice