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Conclusion and future perspective IGF-1 exhibits a wide range of functions that are significantly altered in the context of CKD

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FOXO4 facilitates TM3 Leydig cell senescence and maintains the viability of senescent cells To further validate the role of FOXO4 in senescent Leydig cells, we silenced FoxO4 expression using siRNA prior to senescence induction

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2021;320:G983-g989

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1. Reduces skin wrinkles and improve elasticity 2. Skin whitening 3. Anti-aging

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