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Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
doi: 10.1016/S1875-5364(22)60172-9 145
A plausible explanation for such adaptations is that these processes reduce stress-induced mutations in mtDNA, which is important as they lack protective histones or repair mechanisms
Although the study provided initial evidence linking depression with 8-iso-PGF2, it was limited by a small sample size and the presence of comorbidities in some elderly subjects that could skew the results
