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GlyT1 inhibitor M22 treatment increased the seizure threshold in a mouse model of the maximal electroshock seizure threshold (MEST) test without affecting motor function, suggesting its potential as a new anticonvulsive drug but in this same study M22 was ineffective in altering the seizure threshold as assessed by the PTZ infusion test (Zhao et al

Nanoformulation of Olaparib Amplifies PARP Inhibition and Sensitizes PTEN/TP53-Deficient Prostate Cancer to Radiation

Part of the antioxidant pathway, PER peroxidase, IDHP dehydrogenaseand ACO3M hydratase, were also up-regulated, and peroxidase was able to reduce oxidative damage by catabolizing reactive oxygen species during salt stress, as well as enhance plant salt tolerance through gene expression regulation, and changes in its activity were closely related to plant salt tolerance [46,47,48]

doi:10.1021/ic50222a011