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Some patients find that taking their supplement with the largest meal of the day provides optimal tolerance

[DOI] [PMC free article] [PubMed] [Google Scholar] 144.Rothenberg M.E., Mishra A., Collins M.H., Putnam P.E

[DOI] [PubMed] [Google Scholar] 10.Cotgreave I.A

When NADPH binds to the oxidized SjTGR, it transfers the electrons sequentially to FAD, to the nearby C154/C159 redox couple, then to C596/U597 redox active couple on the C-terminal segment of the neighboring subunit, and ultimately to either various downstream oxidized substrates such as SjTrx1 and SjTRP14 or back to the redox-active C28-C31 motif in the Grx domain of the neighboring monomer to reduce GSSG (Fig 7)