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It is activated when a signaling molecule binds to a receptor on the cell surface, leading to PI3K activation and subsequent production of phosphatidylinositol (3,4,5)-trisphosphate (PIP3)

MOR202 and Mezagitamab bind with high specificity to CD38 on the surface of multiple myeloma cells 150,151 inducing apoptosis through ADCC and antibody-dependent cellular phagocytosis (ADCP) 152,153

The peptide, derived from the C-terminal fragment of human growth hormone (amino acids 176-191), targets adipose tissue specifically without the broader metabolic effects associated with full growth hormone therapy

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